Objective
Despite that many human diseases are caused by bacterial pathogens, not much is known about how these pathogenic bacteria emerge. The alpha-proteobacterial order Rickettsiales comprises intracellular bacterial pathogens, including the causative agent of epidemic typhus, Rickettsia prowazekii. The overall aim of the current project is to gain insight in the evolutionary transition from free-living bacterium to (human) pathogen, using the Rickettsiales as a model system. To do so, deeply branching Rickettsiales lineages will be isolated from environmental samples and from amoeba that contain Ricketsiales-like endosymbionts. Free-living Rickettsiales species will be isolated from the Sargasso Sea using a single-cell genomics approach. In parallel, protist-associated Rickettsiales species will be isolated from amoeba. Subsequently, an attempt will be made to determine the complete genome sequence of the obtained free-living and ciliate-associated Rickettsiales species. By comparing the obtained genomic data with that of their pathogenic relatives, principle differences will be revealed that should give insight in the evolutionary transition from free-living bacterium to human pathogen. The proposed study aims at enumerating a number of pathogenicity genes that could represent excellent targets for vaccine development for treatment of infections caused by pathogenic Rickettsiales species.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences genetics genomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
751 05 Uppsala
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.