Peptide Dendrimers - A Chemical Platform for Functional Diversity

Projektinformationen

PEPTIDE DENDRIMERS

ID Finanzhilfevereinbarung: 254897

Abgeschlossenes Projekt

Startdatum 13 Juni 2011

Enddatum 12 Juni 2014

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 240 817,90

EU-Beitrag € 240 817,90

Koordiniert durch

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain

Ziel

Peptides have emerged as a therapeutically important class of drugs and offer the advantage of great specificity, potency and low toxicity. Short circulation half-life, poor proteolytic stability and bioavailability have however prevented them from becoming a mainstream source of drug candidates. Dendrimers are versatile, derivatizable, well-defined branched synthetic macromolecules with promising properties for a variety of applications in technology and medicine. Combining therapeutic peptides with dendrimers represents a promising approach to overcome bioavailability limitations, while at the same time introducing novel pharmacological and biophysical properties. The impact of the dendritic structure and multivalency on potency, selectivity, bioavailability and overall pharmacology will be studied on nicotinic acetylcholine and oxytocin/vasopressin G-protein coupled receptors, two important biomedical targets. A synthetic strategy based on efficient ligation chemistry and combinatorial assembly of building blocks will form the platform for the assembly of diverse multifunctional peptide dendrimers. These peptide dendrimers will undergo detailed structural, biophysical and pharmacological characterization for their use as diagnostic tools and therapeutics.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › biochemistry › biomolecules

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2009-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-IOF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IOF - International Outgoing Fellowships (IOF)

Koordinator

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)

Kontakt Verwaltung

Alexandre Puerto (Mr.)

• EU-Beitrag: € 240 817,90
• Adresse: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA ; 08028 Barcelona ; Spanien
• Region: Este › Cataluña › Barcelona
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten