Peptide Dendrimers - A Chemical Platform for Functional Diversity

Project Information

PEPTIDE DENDRIMERS

Grant agreement ID: 254897

Project closed

Start date 13 June 2011

End date 12 June 2014

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 240 817,90

EU contribution € 240 817,90

Coordinated by

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain

Objective

Peptides have emerged as a therapeutically important class of drugs and offer the advantage of great specificity, potency and low toxicity. Short circulation half-life, poor proteolytic stability and bioavailability have however prevented them from becoming a mainstream source of drug candidates. Dendrimers are versatile, derivatizable, well-defined branched synthetic macromolecules with promising properties for a variety of applications in technology and medicine. Combining therapeutic peptides with dendrimers represents a promising approach to overcome bioavailability limitations, while at the same time introducing novel pharmacological and biophysical properties. The impact of the dendritic structure and multivalency on potency, selectivity, bioavailability and overall pharmacology will be studied on nicotinic acetylcholine and oxytocin/vasopressin G-protein coupled receptors, two important biomedical targets. A synthetic strategy based on efficient ligation chemistry and combinatorial assembly of building blocks will form the platform for the assembly of diverse multifunctional peptide dendrimers. These peptide dendrimers will undergo detailed structural, biophysical and pharmacological characterization for their use as diagnostic tools and therapeutics.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › biochemistry › biomolecules

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2009-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development"

Call for proposal

FP7-PEOPLE-2009-IOF
See other projects for this call

Funding Scheme

MC-IOF - International Outgoing Fellowships (IOF)

Coordinator

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)

• EU contribution: € 240 817,90
• Address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA ; 08028 Barcelona ; Spain
• Region: Este › Cataluña › Barcelona
• Activity type: Research Organisations
• Total cost: No data