Objective
The HIPODERM application seeks support under the Marie Curie Industry-Academia Partnerships and Pathways scheme to facilitate the growth of a dynamic research team for 'the development of novel dermal-translocation, high-potency drug delivery systems'. Our aim is to develop a core scientific platform from which novel non-invasive drug delivery systems can be developed and clinically assessed. At the core of this project lies the hypothesis that microneedle assisted topical drug delivery has failed to fulfil expectations because researchers have routinely over estimated the scale of permeation enhancement possible using passive microneedle treatment and also, in general, have targeted unsuitable therapeutic molecules. This project aims to address both of these issues by developing new formulation and fabrication approaches. Combining physical disruption of the stratum corneum barrier with microneedle arrays and a number of active permeation enhancement techniques (such as iontophoresis and phonophoresis) will produce a range of novel hybrid permeation enhancement systems (HPES). The project will focus on high potency therapeutics possessing low therapeutic concentrations that make only realistic demands on delivery systems. Such high potency materials are of increasing importance in therapeutics but are inherently difficult to work with because of the health and safety implications of their high activity. The project pools the expertise of a number of international partners with particular expertise in specific aspects of the approach.
Three clinically interesting target areas have been identified for evaluation:
1. Locally delivered chemotherapeutic agents for the treatment of cancers of the skin and underlying tissues
2. Enhanced localised delivery of potent photosensitisers for photodynamic therapy (PDT)
3. Local and systemic delivery of therapeutic peptides
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IAPP
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)
Coordinator
X91 Waterford
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.