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Content archived on 2024-05-28

Molybdate transport in animals. Role of gephyrin

Objective

Molybdenum (Mo) is an essential micronutrient for almost all living beings. Mo participates as cofactor (Moco) in the active site of more than 50 Mo-enzymes that are involved in vital processes such as inorganic nitrogen assimilation, sulphur metabolism, phytohormone biosynthesis, and stress reactions. Mo is acquired by cells in form of the anion molybdate. Molybdate transport process is well known in bacteria, poorly characterized in plants, algae and fungi, and unknown in animals. In animals Moco deficiency leads to a neuronal damage and finally to an early death. Using the green algae Chlamydomonas and on the basis of his previous experience in the identification of the first eukaryotic molybdate transporter (MoT1), the candidate has identified a putative molybdate transporter in humans (C2H2). The main aim of the research project is to characterize the molybdate transport process mediated by the human protein C2HS. This includes the determination of putative interactions of this protein with other proteins like gephyrin, the subcellular localization of C2HS and its tree-dimensional structure. The proposed project will be developed by the applicant in the Institute of Biochemistry of the University of Cologne under supervision of Prof. G. Schwarz. The quality of the infrastructures and facilities of the University of Cologne, the experience of the host group in the field, as well as a good defined work plan supporter by an appropriated methodology, guarantee a good training for the candidate that will be crucial for him to obtain the skills necessaries to reach a position of professional maturity.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2009-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

UNIVERSITAT ZU KOLN
EU contribution
€ 162 661,00
Address
ALBERTUS MAGNUS PLATZ
50931 KOLN
Germany

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Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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