Objective The global frequency of neonatal sepsis is 1-21 newborns per 1000 live births with mortality rates as high as 35-70%, amounting to 100,000s of annual cases. The consortium has identified a real and pressing need for increasing diagnostic efficacy in a setting that imposes a dramatic healthcare burden on EU (and global) healthcare management systems. The goal of this project is the realization and clinical validation of a fully integrated and automated platform for the parallel detection of neonatal sepsis markers and a panel of sepsis-causing bacteria from a clinical sample (whole blood, cerebrospinal fluid, fluid from joint aspirations or urine). For the first time, this will allow a fast (90 minutes) automated routine diagnosis of neonatal sepsis, permitting a timely and especially specific treatment.The project has the potential to significantly reduce neonatal mortality and ensure appropriate treatment for one of the most vulnerable patient cohorts in the medical setting: newborns. The interaction between presence of microbial pathogens and the host (patient) response will be investigated in a clinical validation phase with a view to planning patient management more appropriately. In the long term this will also reduce the spread of multiresistant strains emerging from the unspecific use of broad-spectrum antibiotics.ASCMicroPlat will cover the complete value chain from research and development to clinical validation. The system will be based on the centrifugal microfluidic platform of HSG-IMIT and an inventive foil-technology for the disposable test carriers, which is scalable to industrial production. ASCMicroPlat will enable a sepsis diagnosis based on a “sample in – result out” process. Additionally, the know-how generated in this project will provide innovative European SMEs with a platform for the fast implementation of lab-on-a-chip tests. The consortium has a strong industrial component including 2 SMEs. Fields of science natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicssocial sciencessociologydemographymortalitynatural sciencesbiological sciencesmicrobiologybacteriologyengineering and technologyother engineering and technologiesmicrotechnologylab on a chipmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.1.2-1 - Tools for the identification and the detection of biomarkers in clinical samples and patients. FP7-HEALTH-2010-two-stage. Call for proposal FP7-HEALTH-2010-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator HAHN-SCHICKARD-GESELLSCHAFT FUR ANGEWANDTE FORSCHUNG EV EU contribution € 668 254,00 Address WILHELM SCHICKARD STRASSE 10 78052 Villingen Schwenning Germany See on map Region Baden-Württemberg Freiburg Schwarzwald-Baar-Kreis Activity type Research Organisations Administrative Contact Saskia Scherer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Ireland EU contribution € 488 315,00 Address COLLEGE GREEN TRINITY COLLEGE D02 CX56 DUBLIN 2 See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Deirdre Savage (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ROHRER AG WERKZEUG- & MASCHINENBAU Switzerland EU contribution € 244 975,00 Address BREMENSTALLSTRASSE 1 4313 MOHLIN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Reto Kägi (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Mobidiag Oy Finland EU contribution € 485 083,00 Address Tukholmankatu 00290 Helsinki See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Antti Ojala (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHIMERA BIOTEC GMBH Germany EU contribution € 75 000,00 Address EMIL-FIGGE-STRASSE 76A 44227 DORTMUND See on map Region Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Detmers (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
