Objective
Few tasks executed by the brain hold greater survival and adaptive value than keeping us fed and in adequate nutritional state. The regulation of energy metabolism represents a prototypical homeostatic system, with the brain acting as the central coordinator. Any alteration of these mechanisms can lead to pathological states threatening the survival of the individual.
The main brain region regulating food intake behaviour is the hypothalamus. The endocannabinoid system (ECS), formed by cannabinoid receptors, their endogenous ligands (endocannabinoids) and the enzymatic machinery for the synthesis and degradation of endocannabinoids is centrally involved in the regulation of food intake.
This project aims at defining the mechanisms of the ECS-mediated control of food intake. We will reach the following goals:
1.We will generate advanced genetic tools allowing conditional deletion, rescue and overexpression of ECS elements. The integrated use of these tools will lead to the detailed mapping of the brain neurocircuitries where the ECS controls food intake.
2.We will provide strong evidence pointing to differential functions of the ECS in food intake, depending on the specific circuits activated.
3.We will determine which endocannabinoid(s) are involved in specific aspects of food intake.
4.We will detail the electrophysiological impact of the ECS on the hypothalamic neuronal network regulating food intake.
5.We will identify novel biochemical mechanisms, linking the ECS to hypothalamic neuronal activity, mitochondrial functions and regulation of food intake.
This project has the ambitious aim to explore new scientific avenues and to provide “in depth” knowledge on the neuronal mechanisms regulating ingestive behaviour in mammals. The results of this project will pave the way to novel lines of research for the physiology and pharmacology of the ECS in the control of energy balance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine physiology
- natural sciences biological sciences zoology mammalogy
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-StG_20091118
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.