Objective Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased risk for pancreatic cancer indicate, that the tumour microenvironment is of particular importance for carcinogenesis in the pancreas. The long-term objective of this proposal is to increase survival of pancreatic cancer patients by exploring the contribution of the tumour microenvironment to the failure of presently available oncological treatments. For this purpose the clinical observation will be reverse-translated into innovative in-vitro and mouse models closely mimicking the human disease. This will allow a profound study of the mechanistic basis of treatment failure by deciphering the complex network between components of the microenvironment and cancer cells leading to increased resistance to chemotherapy and infiltrative growth along adjacent lymphatic and neural structures as well as metastatic spread. Identification of cancer (stem) cell-autonomous as well as stromal-derived mediators of invasion and chemoresistance will lead to novel drug targets to overcome the current therapeutic dilemma. The consortium has been specifically designed to include all required levels of expertise: 1) surgical and medical oncology groups conducting the largest clinical trials for pancreatic cancer in Europe, 2) expert pancreatic pathologists, 3) basic scientists focused on the study of carcinogenesis and tumour microenvironment interactions in the pancreas, 4) molecular oncology groups that have developed genetically engineered mouse models faithfully recapitulating human pancreatic cancer, as well as 5) pharmaceutical industry specialised on drug development. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicineoncologypancreatic cancer Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.1-6 - Translational research on cancers with poor prognosis. FP7-HEALTH-2010-two-stage Call for proposal FP7-HEALTH-2010-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator PHILIPPS UNIVERSITAET MARBURG EU contribution € 626 777,00 Address BIEGENSTRASSE 10 35037 Marburg Germany See on map Region Hessen Gießen Marburg-Biedenkopf Activity type Higher or Secondary Education Establishments Administrative Contact Sandra Basenau (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (16) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 248 800,00 Address BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Veronica Shaw (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III Spain EU contribution € 550 000,00 Address C MELCHOR FERNANDEZ ALMAGRO 3 28029 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Laura Bertolini (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI VERONA Italy EU contribution € 145 000,00 Address VIA DELL ARTIGLIERE 8 37129 Verona See on map Region Nord-Est Veneto Verona Activity type Higher or Secondary Education Establishments Administrative Contact Enrico Cazzaroli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET GREIFSWALD Germany EU contribution € 270 000,00 Address DOMSTRASSE 11 17489 Greifswald See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald Activity type Higher or Secondary Education Establishments Administrative Contact Andrea Völker (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 207 560,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Rolf Trana (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Axcentua Pharmaceuticals AB Participation ended Sweden EU contribution € 72 440,00 Address Alfred Nobels Alle 10 14152 Huddinge See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael-Robin Witt (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Germany EU contribution € 131 400,00 Address ISMANINGER STRASSE 22 81675 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Schaulin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Bayer Pharma AG Germany EU contribution € 76 462,00 Address Muellerstrasse 178 13353 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Delia Nölte (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CANCER RESEARCH UK LBG Participation ended United Kingdom EU contribution € 144 365,00 Address 2 Redman Place E20 1JQ LONDON See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Administrative Contact Emma Ryley (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LAB 21 LIMITED Participation ended United Kingdom EU contribution € 20 758,00 Address Cambridge Science Park 184 CB4 0GA Cambridge See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anthony Cooke (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR Italy EU contribution € 60 000,00 Address Via Olgettina 60 20132 MILANO See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Mario Valsecchi Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution € 60 000,00 Address VIA GIUSEPPE VERDI 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Antonio Baldassarre (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATIMAB THERAPEUTICS SRL Italy EU contribution € 45 000,00 Address VIA RIBES 5 10010 COLLERETTO GIACOSA TORINO See on map Region Nord-Ovest Piemonte Torino Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gianni Garotta (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONCENTRIS RESEARCH MANAGEMENT GMBH Germany EU contribution € 202 838,00 Address Ludwigstr. 4 82256 FURSTENFELDBRUCK See on map Region Bayern Oberbayern Fürstenfeldbruck Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ameli Schwalber (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITAET MUENCHEN Germany EU contribution € 138 600,00 Address Arcisstrasse 21 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Katrin Hörmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE CENTRO SAN RAFFAELE Italy EU contribution No data Address VIA OLGETTINA 60 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Maria Rosa Pedrazzi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data