Objective
The endocannabinoid system is composed of endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), their metabolizing enzymes and cannabinoid receptors. To date, two cannabinoid receptors have been identified by molecular cloning, the CB1 and CB2 receptors. The endocannabinoid system has been implicated in a number of physiological functions, and pharmacological manipulation of this system is a promising therapeutic target in a large number of different diseases and conditions, including mood and movement disorders, obesity, neuropathic pain and cancer, etc. In neurons, release of endocannabinoids can be initiated by calcium signal or by stimulation of G-protein-coupled receptors (GPCRs). Anandamide production may be regulated by a number of lipid modulating enzymes, whereas 2-AG is produced by diacylglycerol-lipases (DAGLs). Stimulation of AT1 angiotensin II receptor and other Gq-coupled-receptors leads to DAGL dependent production of endocannabinoids, but the exact mechanism of this response has not been elucidated. The mechanism of action of GPCRs involves both G-protein-dependent and -independent pathways. G-protein-independent pathways are mediated by beta-arrestin-dependent scaffolding and regulation of signaling complexes. Although the role of these proteins during AT1R signaling is well documented, their function in the G-protein independent signaling of CB1R is not known. The aim of the present project is to elucidate the role of beta-arrestin mediated signaling in the regulation of endocannabinoid production, and to elucidate the role of G-protein-independent signaling in CB1R function. The proposed project includes in vitro studies using molecular biology techniques and in vivo experiments using genetically altered mouse models to elucidate these questions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- medical and health sciences health sciences nutrition obesity
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1085 BUDAPEST
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.