Objetivo We aim to establish a multidisciplinary research program inspired by nature s ability to selectively and specifically control the formation of complex materials, in order to develop new catalytic reactions, generate new materials and delineate new synthetic strategies. The performance of enzymes - complex catalysts perfected though millions years of evolution - offer ideals of selectivity and specificity that synthetic chemistry can aspire to. This proposal aims to establish a multidisciplinary approach to develop new practical and predictable catalytic methods based upon and inspired by natural catalysts. We aim to challenge preconceptions about the field of organic synthesis to focus on the development of asymmetric electrocyclization processes, an entire class of reactions for which there is no general solution. We have delineated an ion-pairing approach to the only catalytic asymmetric thermal 6À electrocyclic process and we aim to build on the insight provided by this result to develop a general approach to the control of electrocyclic processes. We also aim to investigate the development of unnatural folded materials that plagiarize some of the features of enzymes - such as positive cooperativity between non-covalent interactions to generate more efficient asymmetric catalysts. This multidisciplinary approach focuses on the design and synthesis of new folding backbones, investigation of their folding propensities and the evolution of catalytic function. This research program will lead to the development and understanding of new tools essential for the assembly of complex molecules with biological, material or structural value. Ámbito científico natural scienceschemical sciencescatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Convocatoria de propuestas ERC-2010-StG_20091028 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Aportación de la UE € 1 499 993,00 Dirección WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Reino Unido Ver en el mapa Región South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Stephen Conway (Dr.) Investigador principal Martin Derwyn Smith (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Reino Unido Aportación de la UE € 1 499 993,00 Dirección WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Ver en el mapa Región South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Stephen Conway (Dr.) Investigador principal Martin Derwyn Smith (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
