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Content archived on 2024-05-30

Chemical biology of natural products in plant-bacteria interactions

Objective

This project deals with the elucidation of the biological role of natural products in plant-bacteria interactions. Plant-associated bacteria synthesize a vast number of biologically active natural products that modulate the physiology and functioning of their host plants. For example, plant pathogens often cause devastating crop losses by secreting low molecular weight
phytotoxins, while some symbiotic bacteria biosynthesize plant-protecting compounds that assist in lowering biotic and abiotic plant stresses. It is therefore surprising that although natural products seem to play key roles in the complex interaction network between bacteria and plants, most of their biological functions and molecular targets are still unknown.
To date, almost all studies on plant-bacteria interactions have been performed with biological approaches. Here, we propose to investigate the biological role of plant-associated natural products with the aid of a chemistry-driven approach, relying on the power of chemical synthesis to i) generate these natural products and/or suitable natural product derivatives, ii) to elucidate their targets in plants, and iii) to apply them in plant-bacteria studies. Although natural products have long been in the focus of chemical research, such a systematic chemistry-driven approach has, to our knowledge, never been performed before in plant-bacteria interactions. Our project will therefore not only serve to i) decipher basic research questions and ii) identify potential lead structures for agricultural and medicinal applications, but will also contribute to iii) the refinement of chemical syntheses strategies, iv) the advancement of target finding approaches and v) the establishment of chemical biology approaches in plant biology.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

ERC-2010-StG_20091028
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-SG - ERC Starting Grant

Host institution

UNIVERSITAET DUISBURG-ESSEN
EU contribution
€ 1 490 900,00
Address
UNIVERSITATSSTRASSE 2
45141 ESSEN
Germany

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Region
Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Beneficiaries (1)

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