Objective
The skin protects the body against environmental insults and to function properly, epidermal keratinocytes maintain a perfect balance between proliferation and differentiation. Alteration of this balance leads to disorders. Some of these diseases are linked to connexin (Cx) mutations. Connexins are widely expressed in all layers of the epidermis but exact roles of connexins in the epidermis are not known. Analysis of disease mutations can be invaluable for understanding connexin function. Connexin mutations causing skin disorders acquired novel properties and some resulted in active hemichannels that caused release of signaling molecules into the extracellular space and alteration of calcium (Ca2+) mechanisms in adjacent cells. Ca2+ plays roles in keratinocyte proliferation and differentiation and alteration of Ca2+ in the epidermis causes skin disorders. Changes in extracellular Ca2+ levels influence keratinocyte intercellular Ca2+ signals and affect their cellular events. Here it is proposed that aberrant hemichannel activities of Cx26 mutations can alter the epidermal Ca2+ balance by releasing metabolites into the extracellular space and interfere with keratinocyte differentiation programs . For this, normal human keratinocyte cell lines transfected with mutant Cx26 will be used to analyze cellular events, changes in metabolites level and Ca2+ metabolism in cells. Further, keratinocytes with mutant Cx26 will be grown to 3D structures that mimic the normal epidermis and effects of mutant channels on cells in 3D configuration and on Ca2+ signaling will be characterized. The ultimate aim is to understand roles of Cx26 in the skin and its disease. This proposal provides an integration opportunity for the applicant to the host organization in order for her to create her own research laboratory and to transfer her knowledge, research and teaching experiences acquired in USA to the host country and research communities in Europe while retaining her partners in USA.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
35430 İzmir
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.