Objective
The prevalence of obesity has increased epidemically, with little hope for effective treatments on the horizon. Rising along with obesity is an aggregation of comorbidities including insulin resistance, hepatosteatosis, dyslipidemia, hypertensionc, coagulopathy, and atherosclerosis known as the cardiometabolic syndrome. With the extent of obesity in an increasingly aging world population, this field begs for further research into the biological consequences of obesity and the associated pathologies. These chronic diseases are profoundly influenced by pathways that lie at the interface of metabolism and inflammation. Despite intense research into the crosstalk between metabolic and inflammatory pathways, there remains a gap in our knowledge regarding the nutritional modification of this crosstalk. What are the nutritional cues that can beneficially modify this crosstalk? Bioactive lipokines offer tools to study this question in depth. This application will address the nutritional modification of the crosstalk between metabolism, inflammation and stress pathways that has been shown to be a major contributor to the formation of atherosclerosis. In this application we propose to study the impact of a lipokine, palmitoleate, on atherosclerosis. Recent studies have shown that palmitoleate, has profound effects on metabolism. Lipokines can be generated from the adipose tissue and exert endocrine effects in distant tissues such as the liver and skeletal muscle. At the cellular level, palmitoleate can enhance insulin signaling and block metabolic stress pathways that could drive inflammation. Here, we will investigate the impact of palmitoleate on atherosclerosis in mice and study the mechanisms of palmitoleate action in major cell types that contribute to atherogenesis. Discoveries arising from this study could have important implications for the understanding the pathogenesis of atherosclerosis and generation of new therapeutic approaches to this devastating disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine pathology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
06800 BILKENT ANKARA
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.