Objective
"The properties of organic molecules are defined by their shape and
functionality. However, the creation of such molecules with control
over both of these features is highly challenging. This proposal
describes novel methodology for simultaneous C-C bond formation with control
over shape (stereochemistry). In particular it focuses
on the stereoselective replacement of boron (which is easy to
introduce) to halides and other heteroatoms, and new ways for
cross-coupling to aromatics without the need for transition metals.
In order to promote the electrophilic halogenation of a boronic
ester, we envisaged the reaction of boronate complex with a halogen electrophile. In preliminary experiments such processes have already
been found to be viable and occur with complete stereoinversion.
Through tuning the nature of the aryl lithium one could envisage
selective halogenation of a broad range of substrates, giving access
to a myriad of stereodefined secondary alkyl halides, including
fluorides. Moreover, alcohols, amines derivatives, thioethers and
selenoethers could all be accessible by the reaction of these new
activated boronic ester ate complexes with suitable electrophiles.
The final part will focus on the (transition metal-free) cross
coupling of secondary alkylboronic esters. We present a conceptually new
approach to this challenging problem by considering the reaction of a
secondary boronic ester with an aryl lithium reagent. Following ate
complex formation, one-electron oxidation would result in
dearomatization leading to a radical cation which would trigger a
1,2-migration/rearomatization sequence. High stereointegrity can be
expected for such a process from the stereospecificity of the
1,2-sigmatropic rearrangement. Preliminary results have shown that
the concept is again viable but needs substantial optimization. This methodology will be applied to
challenges in synthesis."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences inorganic chemistry alkali metals
- natural sciences chemical sciences inorganic chemistry halogens
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences chemical sciences inorganic chemistry metalloids
- natural sciences chemical sciences organic chemistry amines
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BS8 1QU Bristol
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.