Objective
microRNAs (miRNAs) are novel gene circuitry regulators with an elusive role in neuronal development and plasticity. These small non-coding RNA molecules may explain some of the dysfunctional mechanisms in mental disorders, and are promising targets for diagnosis and treatment of neuropsychiatric disorders. I have recently identified pre-synaptically enriched miRNAs, of which miR-338 was found to modulate the mitochondrial function. This fellowship will allow me to use the knowledge I have gained on the roles of synaptic translation in neuronal development and plasticity as a Research Associate in USA and implement that knowledge to Europe. The three main objectives of my proposed research are: (1) to identify candidate miRNAs differentially expressed during hippocampal development and plasticity; (2) to delineate miRNA’s regulatory role on local protein synthesis which is required for synaptic plasticity; and (3) to determine the functions of miRNAs in neuronal development and plasticity. To address objectives 1 and 2, I will employ deep-sequencing to identify miRNA genes differentially and spatially expressed during experience-dependent synaptic plasticity in the rat hippocampus and its synaptic compartments, respectively, and carry out computational prediction followed by experimental confirmations to identify miRNAs involved in synaptic function. In objective 3, I will investigate miRNA function in different forms of synaptic plasticity using cell biological approaches combined with in vivo behavioral experiments. I anticipate that my interdisciplinary research approach will define the role of miRNAs in synaptic plasticity and memory storage. The research proposed is innovative and significant because it may establish a new avenue of research on synaptic pathophysiology in mental disorders, and may provide the European society with cutting-edge technology with the potential to generate new miRNA-based therapies to treat nervous system disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine psychiatry
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.