Objective "The chemotherapeutic drugs cisplatin and paclitaxel are used in the treatment of ovarian cancer. However, the rate of relapse after therapy is high and is often due to the development of drug resistance. Drug-resistant cancer cell lines in the laboratory frequently have an inverse resistance relationship between cisplatin and paclitaxel. When cisplatin resistance occurs, cells are likely to have no change in resistance to paclitaxel and some cells even become more sensitive to paclitaxel. There is also clinical evidence to support the benefit of alternating between cisplatin and paclitaxel therapy in ovarian cancer. The aim of this project is to understand the molecular mechanism of inverse-resistance by identifying genes and proteins associated with the resistance phenotype in a panel of drug-resistant cancer cell lines. One gene which we have associated with the mechanism of inverse-resistance by literature search is BRCA1. This project has three phases 1) Genomic and proteomic profiling of a panel of drug-resistant cell lines; 2) Functional validation of identified targets and understanding of the mechanism of inverse resistance and 3) Investigation of the role of BRCA1 in the inverse-resistance relationship between cisplatin and paclitaxel. Validated molecular markers associated with the inverse-resistance relationship could potentially be used as a clinical test to determine if an individual patient is likely to be resistant to cisplatin or paclitaxel therapy. Patients likely to respond to cisplatin or paclitaxel could be given the appropriate drug, while patients unlikely to respond to either can be given alternative chemotherapy." Fields of science natural scienceschemical sciencesinorganic chemistrytransition metalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesclinical medicineoncology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Call for proposal FP7-PEOPLE-2010-RG See other projects for this call Funding Scheme MC-ERG - European Re-integration Grants (ERG) Coordinator THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN EU contribution € 45 000,00 Address COLLEGE GREEN TRINITY COLLEGE D02 CX56 DUBLIN 2 Ireland See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Deirdre Savage (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
