Objective
Schizophrenia is a highly hereditable psychological disease that affects up to 1% of the world population. This pathology causes devastating neurological symptoms. A great advance in understanding the basic biological processes affected in schizophrenia came from the discovery of some of the genes that when mutated represent a risk factor for the development of the disease, most likely acting in combination among each other and with environmental factors. One of the best established of these susceptibility genes is a called Disrupted-in-schizophrenia-1 (DISC1). DISC1 has been implicated in many fundamental process and it likely to perform many tasks during the normal development and function of neurons. I am proposing to investigate the involvement of DISC1 in the transport of cargoes along the neuronal axon. This phenomenon is of crucial importance for normal brain function since it allows the trafficking of proteins and organelles between the cell body of the neurons and the synapses at the periphery, and vice versa. There are indications that DISC1 may be regulating this bidirectional transport by interacting with microtubule associated motors and that this process may be altered in schizophrenic patients. Using zebrafish I will be able to observe this phenomenon in vivo, with a detail resolution that is not possible in humans or other mammals. Using a combination of experimental tools including, zebrafish mutants for the DISC1 locus, dominant negative approaches and shRNA knock down, I will assay the function of DISC1 in single neurons separating its later role in neuronal function from early ones. The brain of zebrafish larvae is in fact transparent and small enough to allow the direct observations of fluorescent proteins in single axons. Furthermore, these dynamic processes are highly conserved between fish and humans and what we learn from the fish model will tell us more about DISC1 function in humans as well.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
- natural sciences biological sciences zoology mammalogy
- medical and health sciences clinical medicine psychiatry schizophrenia
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.