Objective
"A key to development is the maintenance of various cell identities. Despite identical genome sequence, in a defined organism, cells from different origins will have distinct pattern of gene expression. The chromatin structure plays a pivotal role in the regulation of gene expression and contributes to this so-called ""epigenetic information"". Different parameters defined the chromatin structure among which DNA methylation, histone variant incorporation and histone post-translational modifications (PTMs).
Polycomb Group proteins (PcG) were identified in Drosophila by mutations that result in segmental transformation and are known to be required for proper development in mammals. It was shown that PcG proteins maintain the repressed state of genes throughout development partly by regulating the chromatin structure. The PcG multi-proteins complex, PRC2, is responsible for the methylation of the lysine 27 on the histone H3. This PTM is supposed to contribute to the recruitment of other PcG proteins that altogether maintain gene repression. How is the PRC2 complex targeted to genes in a cell specific manner? What are the factors required? What is the contribution of non-coding RNA? We will try to answer these questions in the first aim of this proposal.
The tumorigenic progression of cells is associated to major rearrangements of chromatin. Not surprisingly, several PcG proteins were found deregulated in cancer. Hence, the PRC2 component Ezh2 is upregulated in many kinds of cancers including prostate and breast cancers. Following the first studies analyzing the function of Ezh2 mostly in cancer cells, it was proposed that Ezh2 could be classified as an oncogene. However recent publications as well as our unpublished results indicate that the function of Ezh2 in tumorigenesis might be more versatile. Using in vivo approaches and focusing on prostate cancer, we will investigate this question."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences zoology mammalogy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.