Objective
A key challenge facing environmental risk assessors is the need to assess the risk of thousands of chemicals, for a wide range of species, with increased accuracy and ecological relevance, while using fewer resources and experimental animals. Traditional external toxicity metrics, such as the lethal aqueous concentration (LC50), are not sufficiently sophisticated to accomplish this task, and “new” approaches are emerging. This includes the tissue residue approach (TRA), which is advocated as a powerful tool to aid and improve ecological risk assessment. Claimed advantages include, a.o. a likely reduction in use of experimental animals, an improved ability to address mixture toxicity, and an improved ability to link laboratory measurements of exposure and effects to the field. Nevertheless, the application of the tissue-residue approach remains limited. This is mainly because internal target site concentrations are difficult to measure. Mechanistic models that enable the conversion of existing external effect data to critical target concentrations are therefore urgently needed. At present, such in silico tools are well-established for persistent organic chemicals acting via polar or non-polar narcosis. Reliable mechanistic models are however scarce for other modes of action. Therefore, we propose to develop mechanistic models that can reliably predict critical target residues from external effect concentrations for other chemicals, including reactive organic chemicals and metals.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.