Objective
Over fifteen percent of the western population suffer from osteoarthritis. For severe disability, total joint replacement remains the onlty treatment. The ageing population is growing and their expectations for an active, high quality lifestyle is increasing. The number of knee joint replacements is predicted to increase five time by 2025. While technology for knee joint replacements has advanced considerably over the last decade, knee joint replacements do yet restore the natural function or provide the longevity expected for a population expecting - fifty more active years after fifty. An alternative is needed.
We wil address the potential of regenerative biological scaffolds to re-engineer and regenerate the knee in early stage degenerative disease. We will build upon our successful research and clinical trials in the application of regenerative biological scaffolds in the cardiovascular system.. We will research and develop bioprocesses to produce a portfolio of tissue specific regenerative biological scaffolds to replace disrupted and degenerative tissues in the knee, including ligaments, meniscus, bone and cartilage. and evaluate their biomechanical, biotribological and biological function. We will investigate the regenerative potential of these novel biological scaffolds individually and collectively in the knee as a bioengineering system.
This research will open the opportunity for a paradigm shift for treatment of degenerative disease in the knee and offer the potential for substantially delaying the need for a joint replacement in hundreds of thousands of patients every year.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-AdG_20100224
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
LS2 9JT Leeds
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.