Objectif Mesenchymal stem cells (MSCs) can contribute to the regeneration of different tissues by differentiating into a wide variety of cell types, including cardiomyocytes, adipocytes and endothelial cells among others. MSCs represent a reliable source of adult stem cells in humans. A recent report suggests that MSCs concentrate around blood vessels, although the MSC natural microenvironment (niche) is not completely understood.In this project, we aim to study the biology of Bone Marrow derived stem cells (BM-MSCs) and Adipose tissue-derived mesenchymal stem cells (ASCs) in their niche and exploit this knowledge for the treatment of myocardial infarction. We will analyze the interaction of these two types of MSCs with blood vessels, identify the molecules involved and compare which one is more effective for cardiac regeneration. Objectives: 1) Determine the effect of blood vessel-derived cells on human and mouse MSCs; 2) Define the interactions between MSCs and blood vessel-derived cells in the human and mouse MSC niche, including the identification of the molecules mediating direct cell contact and the soluble factors mediating the paracrine effect of blood vessels; 3) Determine the role of the identified factors in the MSC niche in vitro and in vivo by using recombinant proteins and neutralizing antibodies; 4) Compare the potential of BM-MSCs versus ASCs for myocardial regeneration and repair, and investigate the capacity of the identified factor s to enhance this potential. The results will contribute to the development of novel therapeutic strategies for the treatment of myocardial infarction.The project will provide specific training for the researcher in the field of human stem cells, cardiovascular research and general issues related to clinical as well as basic human research that will help the transition of her career into translational research. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologycells technologiesstem cells Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2010-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur SERVICIO MADRILENO DE SALUD Contribution de l’UE € 230 980,00 Adresse Paseo De la Castellana, 280 28046 MADRID Espagne Voir sur la carte Région Comunidad de Madrid Comunidad de Madrid Madrid Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Luis J. Fernandez Vera (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée