GENE REGULATORY NETWORK CONTROLLING THE ROOT STEM CELL NICHE IN ARABIDOPSIS THALIANA

Project Information

Stem Cell Regulation

Grant agreement ID: 275988

Project closed

Start date 1 March 2012

End date 28 February 2014

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 168 863,20

EU contribution € 168 863,20

Coordinated by

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany

Objective

Plant stem cells are located in apical meristems at the growing tips of the shoot and the root. Signals from the neighboring organizing center within the shoot or quiescent center (QC) within the root maintain the stem cells in an undifferentiated state. The homeobox gene WUSCHEL-RELATED HOMEOBOX 5 (WOX5) is QC-specifically expressed and plays a central role in the control of the distal stem cells. However, the downstream factors of WOX5 and the molecular events triggered by WOX5 activity are not understood.
Therefore, this project is intended to identify WOX5 primary target genes and to elucidate the roles of factors acting downstream of WOX5 in stem cell regulation. From pilot experiments, the first candidates for WOX5 target genes have been identified. I will perform a thorough transcriptome profiling of the QC, verify candidates by WOX5 protein -DNA binding studies in vivo, and by functional characterization. Furthermore, systems biology approach of the WOX5 downstream factors will be used for the construction of a regulatory network involved in stem cell niche signaling. Taken together, the proposed project will deepen the knowledge of how cell-cell communication in the stem cell niche functions.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › medical biotechnology › cells technologies › stem cells

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Call for proposal

FP7-PEOPLE-2010-IEF
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

• EU contribution: € 168 863,20
• Address: FAHNENBERGPLATZ ; 79098 Freiburg ; Germany
• Region: Baden-Württemberg › Freiburg › Freiburg im Breisgau, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data