Objective
"The aim of the proposed research is to develop a new (Au-NP) gold nanoparticle-based drug delivery systems. For this new synthetic approach, three different components are designed; namely, new tailored gold nanoparticle, cleavable linkers, and new platinum-based drugs.
The first component is a new tailored Au-NP, which will be synthesized using a multidentate thioether “coating ligand”. Unlike the gold nanoparticle-based nanocarriers used till date, this novel nanomaterial enables accurate functionalization of the particle surface using a multidentate ligand, allowing also controlled particle size and shape. Moreover, tuning of the gold-surface properties is easily performed by functionalization of the coating ligand, leading to a well defined drug load per particle. The functionalization also enables the attachment of linkers (second component of the system) of a programmable variety on the outer-shell of the Au-NP, which will serve as bridges between the nanocarrier and the drug.
The proposed approach is the use of cleavable linkers to reach a new level of drug-controlled release. Inspired by cancer biology, peptide linkers will be attached to the coating ligand of the gold nanoparticle. These peptides will be cleaved by overexpressed proteases in cancer tissue, achieving tumor-specific drug (endogenous) release. In addition, exogenous activation of drug release using photolabile linkers will be explored, leading to new class of external controlled platinum drug release.
To test this approach, platinum-based drugs (third component), which display high cure rates against several cancers (ovarian, head neck, testicular and lung cancer), will be attached to the nanocarriers using different cleavable linkers. In addition to the synthesis and characterization of these systems, in vitro studies in cancer cells will be performed to investigate their cellular processing, and establish their mechanisms of action."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology lung cancer
- natural sciences chemical sciences inorganic chemistry transition metals
- medical and health sciences medical biotechnology nanomedicine
- engineering and technology materials engineering coating and films
- medical and health sciences clinical medicine oncology head and neck cancer
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3584 CS Utrecht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.