On/Off-Switchable Smart Nanobioreactors

Project Information

SSNano

Grant agreement ID: 275336

Project closed

Start date 16 October 2011

End date 15 October 2013

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 210 092,80

EU contribution € 210 092,80

Coordinated by

CRANFIELD UNIVERSITY
United Kingdom

Objective

Nanobioreactor, a fascinating technology, is a latest combination of nanobiotechnology with advanced functional materials, are becoming promising tools for sensitive and selective novel biosensors. The aim of this research is to develop, synthesize and apply a new generation of stimuli-responsive switch-like nanobioreactors which own the self-switching textural ability to allow the specific recognition of target bioanalytes. The implementation of the project could generate important contributions to the development of stimuli-responsive advanced nano-materials for the various applications, such biocatalysts and nanobiosensors. To achieve the goals, a fundamental route to development of stimuli-responsive advanced materials is showed below: first, cationic polystyrene (PS) particles formed via emulsifier-free polymerization will be used as templates to prepare core-shell hybrid PS/SiO2 via the ammonia-catalyzed hydrolysis and condensation of (3-Mercaptopropyl) trimethoxysilane, Tetraethylorthosilicate and methacryloxypropyltrimethoxysilane. In the second step, cationic PS templates will be removed in toluene solution to form hollow silica particles. Subsequently, Au3+ will be assembled into inner pore of hollow silica through Au-S interaction and then reduced into nanoclusters by sodium borohydride. Finally, N-isopropylacylamide and 2-acrylamide-2-methylpropane sulfonic acid will be alternately grafted onto the surface of hollow silica particles, in the presence of N,N’-methylenebisacrylamide, to form an interpenetrating polymer network. The resulting nanoreactors would be expected to demonstrate on/off switchable behavior upon the contact with external stimuli such as temperature.

Fields of science

• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › biosensors
• natural sciences › chemical sciences › inorganic chemistry › alkali metals
• natural sciences › chemical sciences › polymer sciences
• engineering and technology › nanotechnology › nano-materials
• natural sciences › chemical sciences › catalysis › biocatalysis

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2010-IIF - Marie Curie Action: "International Incoming Fellowships"

Call for proposal

FP7-PEOPLE-2010-IIF
See other projects for this call

Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

CRANFIELD UNIVERSITY

Administrative Contact

Martin Ellis (Mr.)

• EU contribution: € 210 092,80
• Address: College Road ; MK43 0AL Cranfield - Bedfordshire ; United Kingdom
• Region: East of England › Bedfordshire and Hertfordshire › Central Bedfordshire
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data