Objectif Translational control determines the rate at which mRNAs are synthesized into proteins; regulates biological processes ranging from apoptosis to memory; and shows deregulation in diseases such as fibrosis and cancer. In cancer, dysregulated translational control is associated with worse prognosis in most sold cancer. Despite this, integrated genome wide knowledge of translational control and its regulatory mechanisms is lacking. My new methods for data analysis and mechanistic discoveries allow, for the first time, efficient genome wide studies of translational control. By using all publicly available genome-wide data sets and these methods we will characterize the landscape of translational control by identifying genes and pathways that are regulated translationally; groups of genes that constitute functional translational modules and show co-regulation across many biological conditions; key genes that are highly connected (nodes) and under translational control; network structures that are regulated at the translational level; and mechanisms that mediate such regulation. This information will be used to compare many biological processes to generate an integrated perspective of translational control. Through functional experiments employing both gene specific and regulatory mechanism focused approaches we will link translational control, genes, mechanisms for regulation and biological processes to unravel a new level of understanding of translational control. Such knowledge will be applicable in future studies of how dysregulation of translational control contributes to human disease. Champ scientifique natural sciencescomputer and information sciencesdata sciencenatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Appel à propositions FP7-PEOPLE-2010-RG Voir d’autres projets de cet appel Régime de financement MC-IRG - International Re-integration Grants (IRG) Coordinateur KAROLINSKA INSTITUTET Contribution de l’UE € 100 000,00 Adresse Nobels Vag 5 17177 Stockholm Suède Voir sur la carte Région Östra Sverige Stockholm Stockholms län Type d’activité Higher or Secondary Education Establishments Contact administratif Maria Von Witting (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
