Objective
After brain injury or neurologic disease, the ability of the central nervous system (CNS) to regenerate is limited. Neural stem cells (NSCs) have the potential to differentiate into neurons and glia, but neurogenesis is incomplete after CNS disease because of a changed extracellular environment. The identification of novel factors responsible for regulating NSC fate is necessary for the molecular understanding of NSC differentiation. In previous work, we have identified that fibrinogen, a blood-derived protein, which is deposited in the nervous system after perturbations of the neurovascular homeostasis, is an inhibitor of neuronal regeneration and an activator of astrocyte scar formation. Fibrinogen interacts with a plethora of receptors and mediates pathways that control cell proliferation and differentiation. Although the signalling machinery necessary for fibrinogen action is present in brain cells, such as NSCs, the role of fibrinogen on NSC differentiation has not been characterized. The central goal of this project is to understand the molecular basis of fibrinogen signalling on NSC proliferation, migration and differentiation. The studies in this project involve the identification and characterization of the NSC/progenitor cell populations, the receptors and signaling mechanisms used by fibrinogen to mediate its effects on regulating NSC fate using state-of-the-art in vivo and in vitro techniques. Understanding how fibrinogen affects neurogenesis at the cellular and molecular levels after CNS injury is important for developing novel therapeutic approaches to promote functional regeneration of the nervous system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
79106 Freiburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.