Objective
Congenital Vascular Malformations (CVM) are a group of diseases characterized by an inborn, localized defects of vascular morphogenesis. Occurring mainly on the face or other highly visible part of the body, the presence of CVM can cause emotional and social problems. Moreover, some malformations are painful or even life-endangering. Current treatments do not achieve optimal or long-lasting results. Thus, there is a pressing need for therapies that are more effective for these disfiguring lesions. Currently, the cellular components of the CVM have not been isolated and analyzed, and there is no animal model for most CVM. One attractive treatment strategy is to induce transdifferentiation of the endothelial cells (ECs) of the lesion. Transdifferentiation is the reprogramming of one specialized cell type into another, without reversion to pluripotent cells.
The goal of my research is to isolate and characterize the EC, the major cellular component of the vascular malformations in order to develop targeted therapy for these lesions. EC and pericytes will be isolated from CVM tissues. We will perform extensive mutational analysis and epigenetic profiling of these primary cells in order to identify any abnormalities in their developmental path. Also, using novel techniques derived from the stem cell field, I will aim at inducing transdifferentiation of the l EC by forced expression of transcription factor pools.
My hypothesis is that reprogramming the EC lining the vasculature of the lesion to a mesenchymal phenotype will lead to obstruction of these vessels and cessation of blood flow, resulting in significant improvement. Importantly, insights gained from this research will have wide implications for the vascular biology field. Thus, this project is novel and innovative.
Having both extensive research experience with the study of angiogenesis and clinical expertise in Dermatology, I’m well-suited for the conduction of this project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine dermatology
- social sciences sociology social issues
- medical and health sciences medical biotechnology cells technologies stem cells
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
52621 Ramat Gan
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.