Objective
The protein environment that surrounds metalloenzyme active sites imparts a wide range of effects that facilitate catalysis. Supramolecular supports for homogenous catalysis may model a number of these effects. However, the use of dendrimers or polymers to provide directed second coordination sphere effects is limited by their unpredictable/unstable structures. Foldamers, based on aromatic amide units, have structures that are both highly stable and predictable in a wide range of solvents. These qualities and the modular approach to their synthesis allows for engineering of cavities of defined size with an organized array of functional groups. This project plans to explore the application of foldamers as supramolecular supports for small molecule mimics of metalloenzyme active sites, specifically [FeFe]-hydrogenase, and in doing so develop a new generation of hydrogenase models with a well defined and tunable second coordination sphere. The research involves the in silico design, and chemical synthesis of foldamers that incorporate small molecule models of [FeFe]-hydrogenase. Through electrochemical and variable temperature NMR studies, the effect of the support on the fluxional and electrocatalytic properties of the model complex will be studied. The applicant has experience in the synthesis and characterization of biomimetics of [FeFe]-hydrogenase and the use of supramolecular supports (cyclodextrins) for their encapsulation. Through joining a host lab in France that specializes in the synthesis and structural characterization of aromatic amide foldamers, this expertise in bioinspired catalysts will be transferred via the proposed cooperative work. Additionally the applicant would act as an envoy between the host lab and a group in Germany, with whom the host lab has an established collaboration, for the spectroelectrochemical study of the foldamer complex systems, thus expanding the transfer of knowledge.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences catalysis electrocatalysis
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences polymer sciences
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
33405 TALENCE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.