Objective
"Genome dynamics is known to be affected by abiotic and biotic factors which enrich the diversity among cells and individuals of the same species. Stress induced by pathogens has been demonstrated to impact host genome stability, but little is known about the effect of non-retroviral RNA viruses (NRVs). NRVs carry a RNA genome and no DNA stage is involved during its infection cycle. Therefore, integration of NRVs' sequences into its host genome is not expected. Despite that, integration of a NRV segment into the host genome has been reported in mammals, plants, insects, fungi and bacteria and was suggested to raise new host phenotypes. Additionally, integration of a host segment within a defective NRV's genome has also been reported demonstrating reciprocal sequence exchange between NRV and its host. Although it has been demonstrated that NRV retrotransposition occurs, the nature of that NRV-mediated host divergence is not clear. Here we propose to further investigate the mechanisms and implications of host-genome plasticity due to NRV integration by building a molecular NRV integration model based on the Lymphocytic Choriomeningitis Virus (LCMV), which has been found integrated within its respective hosts genome, the mouse (Mus musculus) as well as the human. This LCMV-based system is design to carry an integration-induced selective marker, which is assumed to enable identification of cells carrying a DNA version of LCMV-derived sequences in vitro and in vivo. Through combining this experimental system with data analysis, it is likely that we'll be able to initiate, select and track such LCMV-derived integration events. The aforementioned system will serve as a model to determine LCMV's integration frequency, mechanisms, as well as possible implications such as somatic and heritable genetic disorders and virus resistance/tolerance phenotype, triggered by non-retroviral RNA viruses' dynamics with their respective host genomes."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences computer and information sciences data science
- medical and health sciences health sciences infectious diseases RNA viruses
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.