Objective
During development and cellular differentiation, cells acquire specific fates by regulating spatially and temporally the expression of certain groups of genes. This correlates with drastic changes in the 3D organization of the genome. A recent discovery from the Gasser lab has demonstrated that in differentiated cells of C. elegans, tissue-specific promoters relocate inward the 3D nuclear space when activated, and maintain this subnuclear position in a tissue-specific manner into adulthood. Another interesting finding is the relocation of heat-shock promoters toward the nuclear periphery after their induction. Altogether, the data strongly suggests a link between the subnuclear relocation of specific promoters and cellular processes.
However, the exact purpose of these chromatin movements is unclear and so is the underlying mechanism, including the responsible components. Therefore, this project aims to understand the mechanism and function of the subnuclear relocation of promoters during development, and following stress induction in C. elegans. This proposal will focus first on the identification of molecular and genetic elements that may be involved in this mechanism. Second, we want to understand how the candidate components we will identify effect the subnuclear promoters' relocation, and understand for the first time the relevance of this kind of chromatin reorganization. We combine genetic manipulations, advanced biochemical methods that we will need to develop and quantitative live imaging approaches to address these questions.
The work is proposed to be carried out under supervision of Prof. Susan Gasser, at the FMI institute which offers state-of-the-art facilities and provides excellent multi-disciplinary training and collaboration opportunities, thus providing the ideal environment for a successful postdoctoral stay. This postdoc experience will mean switching fields and countries which will play an essential role in my professional growth.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4056 BASEL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.