Objectif We propose to seamlessly integrate advanced microelectronics and living neuronal cells in a comprehensive and interdisciplinary approach to significantly advance the understanding of neuronal behaviour. The project includes (a) the development of a novel multifunctional microelectronics chip platform in complementary metal oxide semiconductor (CMOS) technology, which serves to enable (b) key neurobiological and neuromedical research on network dynamics and plasticity of rodent neuronal networks and visual encoding in retinae, and (c) the necessary concurrent development of algorithms and models to efficiently process and maximally harness the unprecedented quality of the obtained data.Neuronal or retinal preparations, such as acute and organotypic brain slices (retinae) or primary cultured, dissociated cells, will be directly placed or grown atop dedicated CMOS microelectronics chips. The chips will feature multiple functions, since neurons carry and pass signals to each other using electro-chemical mechanisms: electrophysiological recording & stimulation, in closed loop & real time, as well as highly spatially resolved impedance measurements and detection of neuroactive chemical compounds. The chips will be capable of delivering any of these functions to arbitrarily selectable individual cells or even subcellular units, and, at the same time, of interacting with a multitude of cells or complete neuronal networks. Along with imaging (light, fluorescence), pharmacological, and/or genetic methods, the developed chip platform will be used to study neuronal network dynamics, synaptic and axonal plasticity, relevant for many brain diseases, as well as visual encoding in the retina. Efficient data handling and spike sorting algorithms will be developed to facilitate these investigations. The multidimensional data will then be used to establish detailed models of neurons and neuronal networks. Champ scientifique natural scienceschemical sciencesinorganic chemistryinorganic compoundsmedical and health sciencesclinical medicineophthalmologynatural sciencesphysical scienceselectromagnetism and electronicssemiconductivitynatural sciencesphysical scienceselectromagnetism and electronicsmicroelectronics Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-AG-PE7 - ERC Advanced Grant - Systems and communication engineering Appel à propositions ERC-2010-AdG_20100224 Voir d’autres projets de cet appel Régime de financement ERC-AG - ERC Advanced Grant Institution d’accueil EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Contribution de l’UE € 2 498 000,00 Adresse Raemistrasse 101 8092 Zuerich Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Chercheur principal Andreas Reinhold Hierlemann (Prof.) Contact administratif Andreas Reinhold Hierlemann (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Suisse Contribution de l’UE € 2 498 000,00 Adresse Raemistrasse 101 8092 Zuerich Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Chercheur principal Andreas Reinhold Hierlemann (Prof.) Contact administratif Andreas Reinhold Hierlemann (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
