Project description
Virtual Physiological Human
Synergy will develop a simulation environment and a decision-support system aiming at enabling deployment of systems medicine. The three core elements are a knowledge base (KB), an inference engine (IE), and a graphical visualisation environment (GVE). The project focuses on patients with chronic obstructive pulmonary disease (COPD).
The KB will include five well established physiological models addressing: 1) Central and peripheral O2 transport and utilization, 2) Pulmonary gas exchange, 3) Regional-lung heterogeneities in ventilation and perfusion, 4) Skeletal muscle bioenergetics, and 5) Mitochondrial reactive oxygen species (ROS) generation. These models will be written in systems biology markup language (SBML) and vertically integrated. Ontologies will be used as the default knowledge-representation system. The KB will include multi-level data from experimental studies (BioBridge), data from a multicentre longitudinal study on COPD phenotyping (PAC-COPD) and public datasets.
The IE will enable to explore associations over the KB, perform transversal multi-scale model integration and related simulations including interactions among O2-availability/O2-utilization, ROS generation, systemic inflammation and abnormal tissue remodelling.
The Web-based GVE will facilitate relevant simulations in a more intuitive way with respect to the state of the art, addressing two main user profiles: bio-researchers and clinicians.The focus will be on underlying mechanisms of COPD phenotypes associated with poor prognosis. Disease model validation and refinement will be done using a well-established, large dataset (ECLIPSE) together with experimental studies designed to test "in silico" generated hypotheses. Besides the use of the simulation environment by bio-researchers for optimal experimental design, the Synergy platform will be a relevant decision-support tool for integrated healthcare strategies aiming at modulating the evolution of COPDs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-ICT-2009-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08018 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.