Objective
"An underexplored aspect in the evolution of biodiversity is the role of interspecific hybridization. Hybridization is hypothesized to increase the functional diversity of adaptive radiations, potentially yielding ecological speciation. Yet, direct evidence for this is lacking. We propose to apply a large-scale, quantitative approach using experimental evolution with yeast to test this fundamental theory of quantitative genetics. Yeast is a powerful system because it permits the simulation of eukaryotic evolutionary processes while allowing easy access to information on geno- and phenotype.
First, we will generate artificial radiations from hybrid and non-hybrid ancestors and expose them to diversifying selection using high-throughput phenotypic microarrays, simulating a heterogeneous fitness landscape. We will then compare the functional diversity obtained in radiations with and without hybrid background. Second, we will test if phenotypic novelty (transgressive segregation) observed in hybrids increases with genetic and phenotypic distance between their parents. Third, to test if there are stereotypical genetic changes accompanying divergence during adaptive radiation we will resequence parallel and divergent selected strains of yeast.
Besides theoretical aspects, these data may reveal applications for commercial exploitation of phenotypic novelty in yeast. An improved understanding of genetic exchange in fungi can also be crucial for medical/veterinary sciences, epidemiology, and conservation biology.
Training in experimental evolution and state of the art technology (SOLiD sequencing and metabolic fingerprinting) are of key importance to the future competitiveness of the fellow. This project delivers the following aspects of the work program: Improvement of EU scientific excellence through new scientific networks, training of a future research group leader both directly and through mobility, and enhancing EU competitiveness through high profile output"
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- agricultural sciences veterinary sciences
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences ecology ecosystems
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
L69 7ZX LIVERPOOL
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.