Objective
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans, is estimated to infect one third of the human population leading to circa two million deaths a year. While many work has been done onto the socio-economic and host factors affecting the different outcomes of the disease, little is still known about the possible influence of Mycobacterium tuberculosis strain variation. Compare to other bacteria, Mtb has very low polymorphism which have prevented until now a detailed study of the evolutionary forces behind this pathogen. With the advent of next-generation sequencing this gap in our knowledge on the population genetics of Mtb with respect other bacteria is starting to close. This project will be aimed to analyze 100 Mtb strains currently being sequenced by the Sanger institute using Illumina technology which added to our previous panel of 30 strains already generated will allow detail population genetics and evolutionary studies with an special focus on the evolution of known Mtb antigens. Collaborations with laboratories with expertise in immunology, transcriptomics and molecular epidemiology will allow us to put in context the consequences of the Mtb genomic variation found in this study.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences public health epidemiology
- natural sciences biological sciences evolutionary biology
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine pneumology tuberculosis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
46020 Valencia
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.