Objective
One of the characteristics of the central nervous system is its plasticity, with for example a remarkable capacity to store new information. It was for long time thought that there was very little plasticity in terms of exchanging cells and that we essentially were limited to the neurons we were born with. It is now well established that new neurons are added to certain regions of the adult brain in most mammals, although it has been very difficult to study in humans.
The proposed project aims to unveil the cell lineage producing new neurons in the adult human brain and to assess the extent of neurogenesis and how it may change in for example aging and neurological and psychiatric diseases. We propose to take advantage of the rapid development of sequencing technology to assess the origin and lineage of new cells in the human brain by phylogenetic fate mapping. This will be combined with the analysis of the turnover of neurons in the adult human brain by a retrospective birth dating methodology which we recently have developed based on the integration of nuclear bomb test derived 14C. This is a cross-disciplinary project that bridges from basic cell and molecular biology, latest generation DNA sequencing technology via clinical medicine and mathematical modeling to nuclear physics.
A possible role for alterations in adult neurogenesis in the etiology of both depression and schizophrenia has recently received much interest. However, the link between neurogenesis and psychiatric diseases is based on a series of indirect indications, mainly in experimental animals. It is pivotal to gain direct information on the relationship between neurogenesis and psychiatric and neurological diseases in humans.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences physical sciences nuclear physics
- medical and health sciences clinical medicine psychiatry schizophrenia
- natural sciences mathematics applied mathematics mathematical model
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-AdG_20100317
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.