Objective
"Allergic disease is a chronic immune-mediated inflammatory disease with an enormous impact on health and well being and a high economic burden in Europe. The increasing incidence in the last decades is well documented and parallels the environmental changes of Industrialized countries. Although there appears to be a link between environmental factors and the high prevalence of allergic disease, the underlying mechanisms remain unclear. However, the environment may influence susceptibility to allergic disease through inherited epigenetic modifications of DNA. Environmental exposures such as diet, drugs, toxins and social environment seem to influence the risk of developing allergy in children. These exposures have been linked to methylation and acetylation of specific immune-related genes. Using a mouse model of allergic asthma, we will investigate epigenetic changes in lung and immune cells to determine whether known epigenetic modifiers influence the susceptibility of allergic asthma in the offspring. Moreover, we will attempt to determine whether the effect occurs pre- or post-natally and will test the effects of epigenetic modifiers on gender and in mouse strains varying in their predisposition to Th2 immunity. The results from these experiments are expected to lead to a new understanding of the interaction between the environment, epigenetic changes and susceptibility to allergic disease. These results may have significant clinical implications on environmental exposure during pregnancy and ultimately may identify strategies to prevent allergic disease in high risk children."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine pneumology asthma
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine allergology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1090 Wien
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.