Dynamic Combinatorial Chemistry at Lipid Membranes

Projektinformationen

DynaMem

ID Finanzhilfevereinbarung: 274181

Abgeschlossenes Projekt

Startdatum 21 Mai 2012

Enddatum 20 Mai 2014

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 184 040,80

EU-Beitrag € 184 040,80

Koordiniert durch

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

Ziel

Molecular recognition at bilayer membranes is key to many vital processes in biology, yet notoriously difficult to study. Aim of this project is to introduce a new technique to this field: dynamic combinatorial chemistry. We propose to adapt reversible thioester chemistry to this end and use it for two different purposes:
(i) Discovering new synthetic receptors that are optimized for operating at the bilayer interface. This should lead to new fundamental insights into what differentiates molecular recognition at the lipid bilayer interface from the corresponding process in solution.
(ii) Unraveling the mode of action of gramicidin antibiotics through covalent capture of the self-assembled superstructures formed upon incorporation of this compound in the bilayer membrane.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › lipids
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2010-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

RIJKSUNIVERSITEIT GRONINGEN

Kontakt Verwaltung

H.D Veldhuis (Dr.)

• EU-Beitrag: € 184 040,80
• Adresse: Broerstraat 5 ; 9712CP Groningen ; Niederlande
• Region: Noord-Nederland › Groningen › Overig Groningen
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten