Cel Molecular recognition at bilayer membranes is key to many vital processes in biology, yet notoriously difficult to study. Aim of this project is to introduce a new technique to this field: dynamic combinatorial chemistry. We propose to adapt reversible thioester chemistry to this end and use it for two different purposes:(i) Discovering new synthetic receptors that are optimized for operating at the bilayer interface. This should lead to new fundamental insights into what differentiates molecular recognition at the lipid bilayer interface from the corresponding process in solution.(ii) Unraveling the mode of action of gramicidin antibiotics through covalent capture of the self-assembled superstructures formed upon incorporation of this compound in the bilayer membrane. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2010-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator RIJKSUNIVERSITEIT GRONINGEN Wkład UE € 184 040,80 Adres Broerstraat 5 9712CP Groningen Niderlandy Zobacz na mapie Region Noord-Nederland Groningen Overig Groningen Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny H.D Veldhuis (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
