Objective
"The origin of simple nervous systems marks a key moment in animal evolution. To identify the genetic processes that underpinned this event, we need to study how neurogenesis occurs in early branching animal groups with simple non-centralised nervous systems. The Cnidaria (corals, sea anemones, jellyfish) are a particularly informative group for such investigations; however studies of cnidarian neural development have been hampered by a lack of appropriate tools for analysing gene function and visualising neurogenesis in these animals. The recent development of experimental assays and transgenic lineages in the cnidarian sea anemone Nematostella vectensis has addressed this problem and we are now able to examine neural development in this ancient phylum in exceptional detail.
ANTSAN proposes to employ these advanced tools to identify and functionally characterise genes that underpin the critical process of establishing neural connectivity (e.g. axon guidance and synaptogenesis) in this species. To achieve this objective, N. vectensis neural cells will be isolated by performing fluorescence activated cell sorting on transgenic animals in which the nervous system is fluorescently labelled. The global gene expression in this cell population will then be documented via microarray analysis. This inventory of neural expressed genes will inform candidate gene selection for the functional studies of neural connectivity, and will also be compared to published datasets from other animals to identify genes with common roles in neural development across the animal kingdom.
The research outcomes of ANTSAN will make a novel and significant contribution to our understanding of the essential factors involved in nervous system development, and of the earliest steps in nervous system evolution. ANTSAN may also contribute to studies of human neurological disorders, by identifying conserved genes with neural functions that have not yet been studied in biomedically relevant species."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
5008 BERGEN
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.