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Characterisation of molecules regulating adult hippocampal neurogenesis

Obiettivo

The hippocampus contains a population of stem cells that continually proliferate to produce new neurons. The development of new markers capable of identifying and isolating defined neural stem cell populations are of utmost importance. Prominin-1 has successfully been used as a marker for the isolation of neural stem and progenitor cells from other brain regions including the mouse embryonic forebrain, the adult SVZ and the postnatal cerebellum. However, its potential as a marker of stem cells in the adult hippocampus remains to be confirmed. The first aim of this proposal is to examine the efficacy of Prominin-1 as a potential marker for the isolation and characterisation of hippocampal stem cells.
We have recently discovered a dormant or latent population of neural precursors in the adult hippocampus that can be triggered to generate new neurons. Identification and characterisation of the molecules that trigger these latent neural precursors to generate new neurons should lead to the development of radical new therapies to treat neurodegenerative conditions that affect the hippocampus. Two candidate molecules (Prominin-2 and AP2-gamma) have been chosen based on preliminary microarray data and will be examined for their ability stimulate hippocampal neurogenesis.

Invito a presentare proposte

FP7-PEOPLE-2010-IIF
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Coordinatore

TECHNISCHE UNIVERSITAET DRESDEN
Contributo UE
€ 226 945,00
Indirizzo
HELMHOLTZSTRASSE 10
01069 Dresden
Germania

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Regione
Sachsen Dresden Dresden, Kreisfreie Stadt
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Beate Brenner (Mrs.)
Collegamenti
Costo totale
Nessun dato