Objective
Parkin, an E3 ubiquitin ligase and a Parkinsons's disease related gene, translocates to impaired mitochondria upon mitochondria intoxication and drives their elimination via autophagy, a process known as mitophagy. Mitochondrial pro-fusion protein Mitofusin (Mfn) was found to be a target for Parkin mediated ubiquitination. In absence of Parkin, Mfn fails to be ubiquitinated, thus accumulates in the mitochondria, leading to increased mitochondria fusion. The host laboratory discovered that Mfn2 has an additional role in tethering mitochondria to endoplasmic reticulum (ER), a structural feature essential for Ca2+ transfer between the organelles and Ca2+ dependent cell death. This project hypothesizes that Parkin dependent ubiquitination of Mfn is crucial in regulating mitochondria-ER tethering and neuronal survival. We therefore aim to (i) address whether impairment of Parkin-dependent Mfn ubiquitination affects mitochondria-ER tethering and death by Ca2+-dependent stimuli; (ii) identify a potential Deubiquitinase (DUB) enzyme opposing Parkin activity in the regulation of Mfn ubiquitination; iii) identify novel interactors of the PINK1/Parkin pathway, regulating Parkin translocation to mitochondria and therefore Mfn steady-state levels. This project will therefore clarify if ER-mitochondria tethering participates in the neurodegenerative pathways controlled by Parkin
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology parkinson
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1211 Geneve
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.