Objective
"Genome stability during chromosome replication can be challenged by drugs affecting fork progression and intra-S DNA damage. While the mechanisms preserving the integrity of replicating chromosomes in response to replication stress induced by exogenous genotoxic events have been widely studied (Branzei and Foiani 2005; Branzei and Foiani 2007), those controlling fork stability under unperturbed conditions are less understood. Specialized networks control the collision between replication forks and transcription; preventing recombinogenic events. The host laboratory has contributed to elucidate the regulatory processes controlling the integrity of replication forks in response to genotoxic events and the architectural pathway protecting chromosome integrity by coordinating DNA replication and transcription. The overarching aim of this proposal is to understand the mechanisms coordinating replication fork progression across transcribed units using budding yeast as a model organism and a combination of mechanistic, genetic and genomic approaches. The first objective would be to identify and characterize the Mec1 and Rad53-mediated checkpoint mechanisms that control fork stability at transcribed regions while the second is to study whether the checkpoint influences the Top2-mediated epigenetic mechanism coordinating S phase transcription. The rationale of the present project is based on the observations that i) transcribed regions cause fork pausing and the collision between replication forks and transcription bubbles is highly coordinated ii) the replication checkpoint response controls the stability of paused forks iii) replication termination is influenced by transcription iv) oncogene activation leads to massive transcription deregulation and replication stress. The expected findings should have important implications for elucidating the cellular mechanisms preventing genome instability and those pathological processes causing genome rearrangements and cancer."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20139 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.