Cel In this project, we propose to explore a new area in biological research aiming at dissecting emerging of properties of the innate immune responses. Our system model is the Natural Killer (NK) cell. Specifically, we will investigate the mechanisms by which these players of innate immunity achieve tolerance to self and participate to immune responses. Multidisciplinary approaches will be combined to achieve groundbreaking results at nanoscopic and macroscopic scales on the following issues:- How NK cells are educated to self-tolerance?- How NK cells distinguish their targets from normal cells?- How NK cells participate to immunological memory?THINK (THe Immune function of Natural Killer cells) is a challenging project supported by an array of preliminary data obtained by our team of investigators in various fields of expertise:- innate immunity and NK cells in human and mouse models- random insertional mutagenesis in the mouse- genome-wide epigenetic, transcriptomic and RNAi analysis and- state-of-the-art optical imaging techniques from intravital biphoton microscopy to the quantification of proteins in nano-sized areas of the cell.THINK is thus a multidisciplinary project that bridges disciplines: immunology, biophysics, genetics and epigenetics. In a scientific perspective, we think that this project will open new technological and scholar horizons, in reassessing the actual concepts on the links between innate immunity, tissue homeostasis and stress response. In a clinical and translational perspective, we also think that this project will help to design innovative NK cell-based therapies and immunomonitoring protocols. Dziedzina nauki medical and health sciencesbasic medicineimmunologynatural sciencesbiological sciencesbiophysicsmedical and health sciencesbasic medicinephysiologyhomeostasisnatural sciencesbiological sciencesgeneticsepigeneticsnatural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS6 - ERC Advanced Grant - Immunity and infection Zaproszenie do składania wniosków ERC-2010-AdG_20100317 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca UNIVERSITE D'AIX MARSEILLE Wkład UE € 2 500 000,00 Adres BOULEVARD CHARLES LIVON 58 LE PHARO 13284 Marseille Francja Zobacz na mapie Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Eric Vivier (Prof.) Kontakt administracyjny Céline Damon (Ms.) Linki Kontakt z organizacją Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITE D'AIX MARSEILLE Francja Wkład UE € 2 500 000,00 Adres BOULEVARD CHARLES LIVON 58 LE PHARO 13284 Marseille Zobacz na mapie Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Eric Vivier (Prof.) Kontakt administracyjny Céline Damon (Ms.) Linki Kontakt z organizacją Opens in new window Koszt całkowity Brak danych
