Cel "Tumor cells can adopt different modes of cell motility. The ability to switch between diverse modes of migration enables tumors to adapt to micro-environmental conditions and to metastasize. The critical pathways and cellular processes underlying the plasticity of tumor cell motility have only begun to be identified.Endocytosis, originally thought of as a device to internalize nutrients and membrane-bound molecules, is emerging as a connectivity infrastructure (which we call ""the Endocytic Matrix"") of different cellular networks necessary for the execution of various cellular programs. A primary role of the Endocytic Matrix is the delivery of space- and time-resolved signals to the cell, and it is thus essential for the execution of polarized functions during cell migration. The molecular mechanisms it uses are, however, ill defined and likely to involve, in addition to extranuclear pathways, also transcriptional programs. In this respect, we have acquired evidence that components of the Endocytic Matrix require de novo gene expression to promote the transition in the mode of tumor cell motility.We propose to identify critical components of the Endocytic Matrix that by controlling the cellular location of actin remodellers promote the plasticity of tumor cell migration. We will also test whether, in addition to the immediate epigenetic/signalling-based control of migration, the Endocytic Matrix regulates transcriptional programs required for the acquisition or maintenance of diverse modes of motility. Finally, in view of the key role of microRNAs (miRNAs) in cancer, we will use miRNA profiling, together with endocytic cell migration and invasion assays in human cancer cells to test whether miRNAs mediate the relationship between endocytosis and motility programs." Dziedzina nauki engineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationstelecommunications networksmobile networkmedical and health sciencesclinical medicineoncology Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS4 - ERC Advanced Grant - Physiology, Pathophysiology and Endocrinology Zaproszenie do składania wniosków ERC-2010-AdG_20100317 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Wkład UE € 2 232 200,00 Adres VIA ADAMELLO 16 20139 Milano Włochy Zobacz na mapie Region Nord-Ovest Lombardia Milano Rodzaj działalności Research Organisations Kierownik naukowy Giorgio Scita (Prof.) Kontakt administracyjny Carlo Raimondi Cominesi (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Włochy Wkład UE € 2 232 200,00 Adres VIA ADAMELLO 16 20139 Milano Zobacz na mapie Region Nord-Ovest Lombardia Milano Rodzaj działalności Research Organisations Kierownik naukowy Giorgio Scita (Prof.) Kontakt administracyjny Carlo Raimondi Cominesi (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
