Objective
The applicant is an experienced researcher with the objective of completing comprehensive training in translational research on Glioblastoma Multiforme (GBM), one of the most common malignant and lethal primary brain tumor of adults, with the final aim of disposing of personalized therapeutic protocols for GBM and cancer patients. The project is based on the finding that human tumors, particularly GBMs, are composed of a mixture of cancer, immune, stromal and vascular cells. The non-cancerous cellular components of the tumor microenvironment appear to play a critical role in tumor development and progression. At UCLA (Los Angeles, U.S.A.) the Mischel Lab has developed the DNA Encoded Antibody Library (DEAL) microarray, to sort specific cellular subtypes from solid tumor samples. The selective capture of tumor cells, lymphocytes, microglia and vascular endothelial cells, directly from GBM biopsy samples, will be obtained by DEAL technology. Genomic and transcriptional analysis will be performed on DEAL sorted cellular subtypes in order to identify novel molecular targets for therapeutic intervention. Genomic and transcriptional findings will be validated with functional assays in model systems: oncogene overexpression, gene silencing and pharmacological inhibition will be applied in order to identify the factors that inhibit the growth and survival of GBMs. In the first phase of the fellowship, at UCLA, the applicant will be utilizing cutting edge nanotechnology and resources that will provide her with outstanding interdisciplinary skills and competences. The applicant will then have the professional maturity to transfer her novel knowledge to the University of Verona (Italy), enriching the scientific excellence of Europe and bridging a new set of collaborations between Italy and the U.S.A.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- engineering and technology nanotechnology
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
37129 Verona
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.