Objectif The remarkable way that Nature prepares complex natural products has always been a source of inspiration to scientists, stimulating the development of new synthetic methods and strategies, as elegantly demonstrated by biomimetic approaches to total synthesis. Similarly, the performance and specificity of enzymes, perfected though evolution, offer ideals of selectivity and specificity that synthetic chemists aspire to. This proposal aims to develop an internationally leading research programme inspired by Nature’s ability to selectively generate diverse products from simple materials with exquisite levels of regio- and enantiocontrol. We aspire to synthetically emulate the elegant behaviour of Nature’s building blocks, such as co-enzyme A, in their ability to generate synthetic diversity (such as polyketides and alkaloids) from a simple and common starting material. Using this blueprint, we intend to selectively control the synthesis of a diverse range of bespoke stereodefined carbo- and heterocycles from readily available starting materials using simple man-made catalysts. We specifically aim to develop new strategies within the field of organic catalysis, focused upon the development of methods for the in situ catalytic generation of chiral ammonium enolates from carboxylic acids and their employment in catalysis. We also propose to develop a comprehensive mechanistic understanding of these processes. In preliminary work we have delineated a simple and efficient approach to this problem by employing chiral isothioureas as asymmetric catalysts, and we aim to build on the insight provided by these studies to develop this powerful concept into a generally applicable synthetic strategy. Champ scientifique natural scienceschemical sciencesorganic chemistryorganic acidsnatural scienceschemical sciencescatalysissocial scienceseconomics and businessbusiness and managementemploymentnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Appel à propositions ERC-2011-StG_20101014 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS Contribution de l’UE € 1 497 005,00 Adresse NORTH STREET 66 COLLEGE GATE KY16 9AJ St Andrews Royaume-Uni Voir sur la carte Région Scotland Eastern Scotland Clackmannanshire and Fife Type d’activité Higher or Secondary Education Establishments Chercheur principal Andrew David Smith (Dr.) Contact administratif Trish Starrs (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS Royaume-Uni Contribution de l’UE € 1 497 005,00 Adresse NORTH STREET 66 COLLEGE GATE KY16 9AJ St Andrews Voir sur la carte Région Scotland Eastern Scotland Clackmannanshire and Fife Type d’activité Higher or Secondary Education Establishments Chercheur principal Andrew David Smith (Dr.) Contact administratif Trish Starrs (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
