Objective
Adaptation is the key concept in Evolutionary Biology. Understanding adaptation has important implications for basic and applied science since adaptation underlies processes such as the ability of species to survive in changing environments, resistance to antibiotics and cancer chemotherapies, and host-pathogen interactions. The recent increase in availability of whole genome sequences makes it possible to search for evidence of adaptation on an unprecedented scale. However, current approaches to the study of adaptation are often exclusively based on a priori candidate genes or on searching for signals of selection at the DNA level giving us a biased and incomplete picture of the adaptive process.
The long-term goal of my research is to understand the molecular process of adaptation and its functional consequences. Towards this end, I will focus on the study of recent transposable element (TE)-induced adaptations in Drosophila melanogaster, which I have already shown to be common and readily detectable. I will apply a multidisciplinary approach in which I will combine genomics, population genetics, computational biology, molecular biology and experimental evolution. I will apply this integrative strategy to putatively adaptive mutations identified in populations from well-described contrasting climates, which will provide an ecological context to the identified mutations facilitating their functional characterization. Specifically, I will (i) identify putatively adaptive mutations in four nature-derived European populations with well-described contrasting climates; (ii) analyze their population genetics and evolutionary history; (iii) connect the adaptive mutations to changes in molecular function; and (iv) connect these changes to organismal phenotype and fitness. To accomplish these objectives I will use state-of-the-art techniques such as next-generation sequencing, allele-specific expression analysis, and computational pipelines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.