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Content archived on 2024-05-30

Study of Endothelial and Osteoclastic cells cooperation for Bone Tissue Engineering applications

Objective

Bone diseases like osteoporosis and osteoarthritis are affecting an increasing number of people worldwide. The short- and long-term consequences are an increasing risk of fractures, total joint replacement and bone grafting. Current treatments of osteoporosis are based on inhibition of bone resorption and at best preserve bone volume but do not improve bone formation together with a high risk of complications like an osteonecrosis of the jaw. Furthermore, in clinical cases of bone loss or during osteoarticular prostheses surgeries, bone autograft remains the ‘gold standard’ for surgeon as bone substitutes or bone filler, respectively. In fact, despite the good clinical results of calcium phosphate materials in the same applications and their advantages over bone autograft, their lack of biological properties is still a major drawback. These examples clearly demonstrate the actual limits of the current clinical solutions in the field of treatment of bone disorders and bone tissue regeneration. A key factor for bone repair is the creation of the vascular network allowing optimal cell colonization and mineralized tissue formation. Recent studies have shown the crucial role of cells responsible of bone resorption (osteoclastic cells) in the initiation bone remodeling but also in the recruitment of blood vessel forming cell (endothelial cells). Taking together, this data can explain major issues caused by bisphosphonates as well as the limited application of synthetic materials for the treatment of bone defect. Thus a better knowledge of the communication between cells would highlight the mechanisms of the vascularisation process. This project aims to characterize the specific interactions between osteoclastic and endothelial cells in order to provide a new route both for the treatment of bone healing disorders and for the functionalization of synthetic bone substitutes. We believe that this strategy will accelerate vascularisation and improve bone tissue regeneration.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2011-CIG
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

UNIVERSITE DE BORDEAUX
EU contribution
No data
Address
PLACE PEY BERLAND 35
33000 BORDEAUX
France

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (1)

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