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Content archived on 2024-06-18

Communication Motifs: Principles of bacterial communication in non-genetically diversified populations

Objective

Cell-to-cell communication is a central aspect for understanding how cells form and organize multi-cellular communities involving progressive cell specialization. Multi-cellularity cell specialization cell communication those keywords are frequently used to distinguish metazoans from bacteria. Yet bacteria can form morphologically complex multi-cellular communities, they can non-genetically diversify and they can communicate. This implies that even prokaryotic networks must possess the properties to facilitate these complex functions. Thus basic network features ( motifs ) determining these functions can be discovered and characterized from studying simpler bacterial networks. We want to focus on communication motifs that are present in the gene-regulatory network of Bacillus subtilis. Our proposed methodology involves a combination of quantitative fluorescence microscopy techniques (QFTLM, FRET), developmental assays, signal transduction studies in controlled micro-environments and information theory to quantitatively characterize communication motifs..

Fields of science (EuroSciVoc)

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Topic(s)

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Call for proposal

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ERC-2010-StG_20091118
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Funding Scheme

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ERC-SG - ERC Starting Grant

Host institution

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
EU contribution
€ 1 496 840,00
Address
SEMINARSTRASSE 2
69117 Heidelberg
Germany

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Higher or Secondary Education Establishments
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Total cost

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Beneficiaries (1)

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