Objective
Despite the remarkable advances in musculoskeletal biomechanics during the last decade, realistic physiological tissue-level strain fields in whole bones are not yet known as these cannot be measured experimentally and the numerical simulations targeting this aim either do not include microstructural and elastic information or investigate a sub-volume with simplified loading. However, this knowledge would be essential for unravelling the relation of micro-structure and function, and for understanding the rules dictating process of mechanosensation for bone remodelling and healing.
The aims of this project are to (I) assess the realistic physiological mechanical environment in cortical bone tissue with previously unmatched accuracy to understand the functional adaptation of the intact microstructure and (II) use this knowledge to investigate the variations observed in altered conditions, e.g. fracture healing.
These goals will be achieved using and unprecedented combination of tools and data of an ovine lower limb model available at the research groups and European collaborators of the host. In Phase 1, organ-scale homogenized finite element (FE) models will be developed which include tissue-specific, experimentally assessed anisotropic micro-elastic properties via a multi-scale homogenization approach and physiologically relevant loading histories from musculoskeletal models to compute macro-scale strain and stress fields. In Phase 2, these local macro-scale stresses will be applied on micro-FE models of experimentally assessed meso-scale tissue volumes to compute the micro-scale strains and stresses. In Phase 3 the developed approaches will be incorporated into a numerical framework suitable for the investigation of altered conditions, e.g. fractures. This will be applied on an established sheep osteotomy model, which is anticipated to elucidate the optimum strain levels required to promote the endogenous healing process, which is of direct clinical relevance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
10117 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.